THIS CHALLENGE WILL RALLY SCIENTISTS WORLDWIDE TO PRODUCE VIABLE THICK-TISSUE ASSAYS THAT CAN BE USED TO ADVANCE RESEARCH ON HUMAN PHYSIOLOGY
The Vascular Tissue Challenge is a $500,000 prize purse to be divided among the first three teams who can
successfully create thick, human vascularized organ tissue in an in-vitro environment while maintaining meta-
bolic functionality similar to their in vivo native cells throughout a 30-day survival period. NASA’s Centennial
Challenges Program is sponsoring this prize to help advance research on human physiology, fundamental space
biology, and medicine taking place both on the Earth and the ISS National Laboratory. Specifically, innovations
may enable the growth of de novo tissues and organs on orbit which may address the risks related to traumatic
bodily injury, improve general crew health, and enhance crew performance on future, long-duration missions.
NASA, in partnership with the nonprofit Methuselah Foundation’s New Organ Alliance, is seeking ways to advance the field of bioengineering through a new prize competition.
The Vascular Tissue Challenge offers a $500,000 prize to be divided among the first three teams that successfully create thick, metabolically-functional human vascularized organ tissue in a controlled laboratory environment.
“The humans who will be our deep space pioneers are our most important resource on the Journey to Mars and beyond,” said Steve Jurczyk, associate administrator for NASA’s Space Technology Mission Directorate in Washington. “The outcome of this challenge has the potential to revolutionize healthcare on Earth, and could become part of an important set of tools used to minimize the negative effects of deep space on our future explorers.”
Related cells that are joined together are collectively referred to as tissue, and these cells work together as organs to accomplish specific functions in the human body. Blood vessels around the cells vascularize, providing nutrients to the tissue to keep it healthy. The vascularized, thick-tissue models resulting from this challenge will function as organ analogs, or models, that can be used to study deep space environmental effects, such as radiation, and to develop strategies to minimize the damage to healthy cells.
Studying these effects will help create ways to mitigate negative effects of space travel on humans during long duration, deep space missions. On Earth, the vascularized tissue could be used in pharmaceutical testing or disease modeling. The challenge also could accelerate new research and development in the field of organ transplants.
“When the Wright Brothers discovered how to control aircraft during flight for aviation in the early 1900s, there was an explosion of progress after this key barrier was removed,” said Dave Gobel, chief executive officer of the Methuselah Foundation. “In the same way, once the ‘vascularization limit’ is solved, via the NASA Vascular Tissue Challenge, there inevitably will be an historic advance in progress and commercialization of tissue engineering applications to everyone’s benefit.”
Competitors must produce vascularized tissue that is more than .39 inches (1 centimeter) in thickness and maintains more than 85 percent survival of the required cells throughout a 30-day trial period. Teams must demonstrate three successful trials with at least a 75 percent success rate to win an award. In addition to the laboratory trials, teams also must submit a proposal that details how they would further advance some aspect of their research through a microgravity experiment that could be conducted in the U.S. National Laboratory on the International Space Station.
The new challenge was announced as part of White House Organ Summit, which highlighted efforts to improve outcomes for individuals waiting for organ transplants and support for living donors. In a related initiative, the Center for the Advancement of Science in Space (CASIS), which manages the International Space Station U.S. National Laboratory, announced a follow-on prize competition in partnership with the New Organ Alliance and the Methuselah Foundation that will provide researchers the opportunity to conduct research in microgravity conditions. CASIS will provide one team up to $200,000 in flight integration support costs, along with transportation to the ISS National Laboratory, support on station and return of experimental samples to Earth. CASIS also announced the winners of the $1 million 3-D Microphysiological Systems for Organs-On- Chips Grand Challenge.
The Vascular Tissue Challenge prize purse is provided by NASA’s Centennial Challenges Program, part of NASA’s Space Technology Mission Directorate. Centennial Challenges, managed by the agency’s Marshall Space Flight Center in Huntsville, Alabama, is NASA’s citizen inventor prize program that invites the nation to help advance the technologies that will enable us to go to Mars and beyond, as well as improve life on Earth. The New Organ Alliance, which is administering the competition on behalf of NASA, is a nonprofit organization focused on regenerative medicine research and development to benefit human disease research and tissue engineering.
NASA is carrying forward its mission to reach out to new frontiers with the announcement today of plans for a “Vascular Tissue Challenge”, a $500,000 prize to be given to the team who can first develop vascular thick tissue that will lay the basis for treatments ranging everywhere from new tissue for burn victims to 3-D organ printing, and providing new organs for all who might need them, when they need them.
NASA has always reached beyond the limits of today. In the early 1960s, then U.S. President John F Kennedy issued a challenge to the science community to land a man on the moon and return him safely to the earth by the end of the decade. Think for a moment of the world in which President Kennedy issued that challenge: less than 2 decades since jet propulsion had come into use, in which a journey to the moon seemed impossible. Only 60 years had passed from the first Wright brothers flight at Kitty Hawk! But when Neil Armstrong laid the first human footprint on the moon’s surface on July 21st, 1969, the seeming impossible had become reality because forward-looking, brave men and women refused to accept false limitations in what they could accomplish.
Just as they did a generation ago, brave men and women at NASA and in the medical research community are looking forward to accomplishing what has been thought impossible: the creation of tissue and organs for all who in need.
As with the moon shot, what seemed a giant task is believed to be within reach. To quote NASA’s website:
Developing this capability will enable new research initiatives that may bring real solutions to organ disease, skin burns and other medical concerns. NASA’s objective for this challenge is to produce viable thick-tissue assays above and beyond the current state of the art technology that can be used to advance research on human physiology, fundamental space biology, and medicine taking place both on the Earth and the ISS National Laboratory. Specifically, innovations may enable the growth of de novo tissues and organs on orbit which may address the risks related to traumatic bodily injury, improve general crew health, and enhance crew performance on future, long-duration mission.